paul brinkmannneuroarchitecture / research

Can your neighborhood change your brain?

How our built environment relates to the aging human brain.

We spend much of our lives in built environments. We live in buildings, move through streets and encounter different spatial and environmental conditions every day. But how is our neighborhood connected to the brain?

The study

Researchers followed 334 older adults in Berlin for approximately two years. Using MRI scans, they examined structural brain changes alongside 25 neighborhood characteristics, including air pollution, population density and land use.

The findings

Several neighborhood characteristics were associated with changes in brain structure, including subcortical gray matter, white matter, cortical integrity and ventricular size. The findings suggest that the physical environment deserves attention in research on healthy brain aging.

What this means for architecture

Architecture shapes more than space. Buildings, streets, green spaces and urban organization shape the conditions in which people live. The study raises a fundamental question: how can we design our built environment to support long-term human health?

Conclusion

The built environment is more than a backdrop to our lives. Understanding its associations with brain aging is an important research task for evidence-based architecture.

Quinones et al. (2026)

Aging in the city: Linking neighborhood features with whole-brain structural and micro-structural changes during aging. Environmental Research, 303, 124671.

original research / doi